Chimeric Toxins: Mechanisms of Action and Therapeutic Applications (Cellular and Molecular Mechanisms of Toxic Action)

Haya Lorberboum-Galski, "Chimeric Toxins: Mechanisms of Action and Therapeutic Applications (Cellular and Molecular Mechanisms of Toxic Action)"
Publisher: C R C Press | 2002 | ISBN: 0415283868 | PDF | 308 pages | 1.3 MB

Bacteria and plants produce powerful toxins that can cause a variety of diseases, some of which are lethal for many animal species. Because of their potency in killing eukaryotic cells, they have been used in the development of novel agents for targeted immunotherapy, and have been termed 'chimeric toxins'. Understanding these mechanisms will open new avenues for the design of novel therapies for the treatment of toxin-related diseases. In this book, the authors review the structure, function and mechanisms of action of chimeric toxins and investigate their therapeutic applications in medicine, including approaches used to design, express and purify these molecules; they also discuss their characteristics and in vivo efficacy.

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