Toxicity and Drug Testing By William Acree

Toxicity and Drug Testing By William Acree
This Book focuses on experimental in vivo and in vitro methods used to measure the ADMET properties (absorption, distribution, metabolism, excretion and toxicity) of potential drug candidates.
Authors from several countries have contributed chapters detailing regulatory policies, pharmaceutical concerns and clinical practices in their respective countries with the expectation that the open exchange of scientific results and ideas presented in this book will lead to improved pharmaceutical products.

Contents:
Part 1 Drug Design
1 Blood Brain Barrier Permeation
2 Diagnostic Accuracy and Interpretation of Urine Drug Testing for Pain Patients: An Evidence-Based Approach
3 Experimental and Computational Methods Pertaining to Surface Tension of Pharmaceuticals
4 Multi-Well Engineered Heart Tissue for Drug Screening and Predictive Toxicology
5 Prediction of Partition Coefficients and Permeability of Drug Molecules in Biological Systems with Abraham Model Solute Descriptors Derived from Measured Solubilities and Water-to-Organic Solvent Partition Coefficients

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